University of California, Riverside

Bourns College of Engineering



Kaustabh Ghosh


Faculty Profile

Faculty Profile

Kaustabh Ghosh

Assistant Professor of Bioengineering
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Ph.D. Biomedical Engineering
State University of New York, Stony Brook, 2006

Materials Science & Engineering 207
University of California, Riverside
Riverside, CA 92521

Telephone: 951-827-4203
Fax: 951-827-6416
E-mail: kghosh@engr.ucr.edu
Personal Webpage
Prior Institutions: Harvard University

Biography

Kaustabh Ghosh is an Assistant Professor in the Department of Bioengineering at UC, Riverside. He is an interdisciplinary biomedical scientist and engineer with research interest in cellular biomechanics, vascular tissue engineering and biomaterials for organ regeneration. Prior to joining UCR, he was a postdoctoral fellow at the Wyss Institute for Biologically Inspired Engineering at Harvard University and a research fellow in the Vascular Biology Program at Children’s Hospital and Harvard Medical School. During his fellowship in the Vascular Biology Program, he investigated the role of mechanical forces in tumor vessel malformations. His subsequent research at the Wyss Institute, which was supported by an NIH/NIBIB T32 Interdisciplinary Research Training Grant, focused on the development of polymeric nanoparticles that selectively target pancreatic islet vessels and deliver anti-inflammatory agents (for autoimmune type 1 diabetes) or bone marrow-derived endothelial progenitor cells (for type 2 diabetes) to promote in situ islet normalization or regeneration. He received his Ph.D. in Biomedical Engineering from SUNY Stony Brook in 2006, where he worked in the laboratories of Richard Clark and Miriam Rafailovich on the development of polymeric hydrogels for wound repair. He obtained his undergraduate degree in Chemical Engineering from National Institute of Technology, Warangal, India in 2001.

Degrees

  • Ph.D. Biomedical Engineering, State University of New York (SUNY), Stony Brook, 2006
  • M.S. Biomedical Engineering, State University of New York (SUNY), Stony Brook, 2002
  • B.Tech Chemical Engineering, National Institute of Technology, Warangal, India, 2001

Awards

  • Postdoctoral Training Grant, NIH/NIBIB (T32) Interdisciplinary Research Training Program, 2008
  • President’s Award to Distinguished Doctoral Students, SUNY Stony Brook, 2006
  • Graduate Student Scholarship, New Jersey Center for Biomaterials, 2004
  • Outstanding Mentor Award, Siemens Foundation, 2004
  • Undergraduate Merit Scholarship, National Institute of Technology, Warangal, INDIA, 1999-2001

Research Areas

Dr Ghosh’s laboratory is pursuing interdisciplinary research at the interface of basic and applied science that is aimed at (1) determining how cell- and extracellular matrix (ECM)-dependent mechanical cues regulate endothelial cell organization into vascular structures in both health and disease, and (2) developing instructive biomaterials that leverage the body’s endogenous endothelial cells to enhance new vessel formation, with an emphasis on harnessing the tremendous vasculogenic and regenerative properties of bone marrow-derived endothelial progenitor cells. To achieve this goal, his lab integrates the multidisciplinary principles and techniques related to cellular and tissue biomechanics, vascular biology, biomaterials science and regenerative medicine. Since both newly forming and mature tissues rely critically on blood vessels for efficient nutrient and oxygen supply, this research has important therapeutic implications for promoting tissue regeneration, ameliorating post-ischemic tissue hypoxia and improving the functionality of artificially engineered tissues and organs.

Selected Publications

  • Ghosh K, Thodeti CK and Ingber DE (2011, in press). Micromechanical Design Criteria for Tissue Engineering Biomaterials. In: Ratner, B., Hoffman, A,. Schoen, F. & Lemons, J., eds. Biomaterials Science: An Introduction to Materials in Medicine – 3rd edition, Elsevier Academic Press.
  • Pan Z, Ghosh K, Liu Y, Nakamura T, Clark RAF, Rafailovich MH. (2009) Traction stresses and translational distortion of the nucleus during fibroblast migration on a physiologically relevant ECM mimic. Biophysical Journal; 96(10): 4286-4298
  • Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE. (2008) Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proceedings of the National Academy of Sciences USA; 105(32): 11305-11310.
  • Ghosh K, Pan Z, Guan E, Ge S, Liu Y, Nakamura T, Ren X-D, Rafailovich M, Clark RAF. (2007) Cell adaptation to a physiologically relevant ECM mimic with different viscoelastic properties. Biomaterials; 28(4): 671-679
  • Ji Y, Ghosh K, Shu XZ, Li B, Sokolov JC, Prestwich GD, Clark RAF, Rafailovich MH. (2006) Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds. Biomaterials; 27: 3782-3792
  • Ghosh K, Ren X-D, Shu XZ, Prestwich GD, Clark RAF. (2006) Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing. Tissue Engineering; 12 (3): 601-613
  • Ghosh K, Shu XZ, Mou R, Lombardi J, Prestwich GD, Rafailovich MH, Clark RAF. (2005) Rheological characterization of in situ crosslinkable hyaluronan hydrogels. Biomacromolecules; 6: 2857-2865.

More Information 

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

College Information

Bourns College of Engineering
446 Winston Chung Hall

Tel: (951) 827-5190
Fax: (951) 827-3188
E-mail: collegeinfo@engr.ucr.edu

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