Jiayu Liao
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Jiayu Liao
Assistant Professor,Bioengineering
RESEARCH INTERESTS Dr. Liao's research includes studies on signal transduction pathways, small ubiquitin-like modifier ligase, G protein-coupled receptors, and lipid receptors. He has developed several high-throughput screening systems for drug candidates. Dr. Liao has made some important discoveries of novel G-protein coupled receptors (GPCRs) particularly associated with taste receptors utilizing bioinformatic methods. Recently he has found evidence for several fatty acid receptors that may play an important role in understanding fatty acid induced insulin resistance and the relationship between obesity and diabetes. PUBLICATIONS Zhou, J., Su,P., Wang, L.,Chen,J., Zimmermann,M.,Genbaces,O.,Afonja,O.,Horne,M.,Tanaka,T., Duan,E.,Fisher, J.,Liao,J., SL., Chen, and Wang,F. (2009) “mTOR supports long-term self-renewal and suppresses medoderm and endoderm activities of human embryonic Stem cells” Proc. Natl. Acad. Sci. USA. 106:7840-7845 Su,H., He,M., Li,H., Liu,Q., Wang,J., Wang,Y., Gao,Y., Zhou,L., Liao, J., Young,JA., and Wang,MW. “Boc5, a non-peptidic glucagon-like peptide-1 receptor agonist, invokes sustained glycemic control and weight loss in diabetic mice” PLoS ONE. 2008 Aug 6;3(8):e2892. Liao,J. (2007) “Protein and cellular engineering with unnatural amino acids” Biotechnol Prog. 2007 Jan-Feb;23(1):28-31 Zhang, R., Yan, P.K., Zhou, C.H., Liao, J., Wang, M.W.(2007) “Development of a homogeneous calcium mobilization assay for high throughput screening of mas-related gene receptor agonists” Acta Pharmacol Sin, 28(1):125-31 Chen D, Liao J, Li N, Zhou C, Liu Q, Wang G, Zhang R, Zhang S, Lin L, Chen KX, Xie X, Nan F, Andrew A. Young AA, and Wang MW. (2007). A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice. Proc. Natl. Acad. Sci. USA 104 943-948 (Published online before print January 9, 2007, 10.1073/pnas.0610173104) (From the cover) Liao J, Tao J, Lin G, and Liu D. (2005). Chemistry and Biology of Sphingolipids. Tetrahedron. 61(20):4715-4733 Sanna MG, Liao J, Jo E, Alfonso C, Ahn MY, Peterson MS, Webb B, Lefebvre S, Chun J, Gray N, and Rosen H. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate (2004). J Biol Chem. 279(14): 13839-48. Rosen H and Liao J. (2003) Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. Curr.Opin.Chem.Biol. Vol.7, (4) 461-468. Li S, Cutler G, Liu JJ, Hoey T, Chen L, Schultz PG, Liao J, and Ling XB.(2003) A comparative analysis of HGSC and Celera human genome assemblies and gene sets. Bioinformatics. 19(13):1597-605. Liao J and Schultz PG. (2003) Three Sweet Receptor Genes are clustered in Human Chromosome 1. Mammalian Genome , ,14,(5):291-301. (Cover). (Corresponding author). Li S, Liao J, Cutler G, Hoey T, Hogenesch JB, Cooke MP, Schultz PG, and Ling XB. (2002) Comparative Analysis of Human Genome Assemblies Reveals Genome-Level Differences. Genomics 80(2): 138-139. Liao J, Fu Y, and Shuai K. (2000) Distinct Roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction. Proc. Natl. Acad. Sci. USA 97:5267-5272. Tan J, Hall S, Hamil KG, Grossman G, Petrusz P, Liao J, Shuai K, and French FS. (2000) Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis. Molecular Endocrinology 14(1):14-26. Liao J, Liu B, Rao X, Kushner SA, Chung CD, Chang D, and Shuai K. (1998) Inhibition of Stat1-Mediated Gene Activation by PIAS1. Proc. Natl. Acad. Sci. USA 95:10626-10631. Liao J, Chung CD, Liu B, Rao X, Jay P, Berta P, and Shuai K. (1997) Specific Inhibition of STAT3 Signal Transduction by PIAS3. Science 278: 1803-1805. Shuai K, Liao J, and Song M. (1996) Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of STAT1. Mol. Cell. Biol. 16: 4932-4941. Hirsch AM, McKhann HI, Reddy A, Liao J, Fang Y, and Marshall CR. (1995) Assessing Horizontal Transfer of nifHDK Genes in Eubacteria: Nucleotide Sequence of nifK from Frankia strain HFPCCcI3. Mol. Biol. Evol. 12:16-21. Gullen G, Valdes M, Liao J, and Hirsch AM. (1993) Identification de Actinobacterias Asisladas de Nodulos de Casuarina, Por Tecnicas Trandcionals Moleculares. Rev. Lat.-Amer. Microbiol. 35:195-200. Liao J, and Zhu S. Field Inversion Gel Electrophoresis for Eukaryotic Chromosome Separation. (1989). Chinese Biochemistry Annual Report. |
