Degrees

Ph.D. Chemistry 2003 (with Harry B. Gray)

California Institute of Technology, Pasadena, CA

B.S. Chemistry 1997 (with Honors)

New York University, New York, NY

Awards

• 2003-2006 Hewitt Medical Fellowship (Beckman Laser Institute, UCI)
•  2004 Young Investigator Travel Award, Society of Molecular Imaging annual meeting
•  2000-2002 NIH Traineeship (Caltech)
•  1997-2000 NSF Graduate Fellowship Award
•  1999 Dow Travel Award (Caltech)
•  1996 NSF Undergraduate Fellowship (USC)
• 1996-1997 George Granger Brown Award in Chemistry for Academic Excellence
•  1995 NSF Undergraduate Fellowship (NYU)
•  1995-1997 New York University College of Arts and Science Merit Award
•  A member of Phi Beta Kappa

Research Area

Biophysical Chemistry
Protein Chemistry
Laser Spectroscopy, Spectroscopy, Optics

Publications

[1] Julia G. Lyubovitsky, Xiaoman Xu, Tatiana B. Krasieva, Bogi Andersen, Bruce J. Tromberg, “Mapping dermal structural assembly in normal and pathological connective tissues with intrinsic signal multiphoton optical microscopy,” (submitted to J. Investigative Derm., December 2006)

[2] Julia G. Lyubovitsky, Xiaoman Xu, Tatiana B. Krasieva, Bogi Andersen, Bruce J. Tromberg, “In situ multi-photon optical tomography of hair follicles in mice” (accepted to J. Biomed. Opt., April 2007)

[3] Christopher B. Raub, Vinod Suresh, Tatiana Krasieva, Julia Lyubovitsky, Justin D. Mih, Andrew J. Putnam, Bruce J. Tromberg, Steven C. George, “Non-invasive assessment of collagen hydrogel microstructure and mechanics using multiphoton microscopy,” Biophys. J. 92, 2212-2222 (2007)

[4] Julia G. Lyubovitsky, Edgar I. Sanchez, Chung-ho Sun, Tatiana B. Krasieva, Bruce J. Tromberg, ”Actin filament formation and mitochondrial energetics of ACBT gliomas probed by two-photon fluorescence microscopy,” (in submission)

[5] Julia G. Lyubovitsky, Tatiana B. Krasieva, Joel A. Spencer, Bogi Andersen, Bruce J. Tromberg, “Imaging corneal pathology in a transgenic mouse model using nonlinear microscopy.”, J. Biomed. Opt. 11, 014013 (2006)

[6] Julia G. Lyubovitsky, Tatiana B. Krasieva, Joel A. Spencer, Bogi Andersen, Bruce J. Tromberg, ”Corneal damage revealed by endogenous cellular fluorescence and second harmonic signals from collagen,” Proc. SPIE 5700, p. 213-217 (2005)

[7] Azin Meshkinpour, Peyman Ghasri, Karl Pope, Julia G. Lyubovitsky, Juha Risteli, Tatiana B. Krasieva, Kristen M. Kelly, “Treatment of Hypertrophic Scars and Keloids with a Radiofrequency Device: A Study of Collagen Effects,” Lasers in Surg. Med. 37 (5): 343-349 (2005)

[8] Julia G. Lyubovitsky, Harry B. Gray, Jay R. Winkler “Conformations of Unfolded S.cerevisiae Cytochrome c Probed by Fluorescence Energy Transfer Kinetics,” Israel J. Chem. 44, 263-269 (2004)

[9] Julia G. Lyubovitsky, “Mapping the Cytochrome c Folding Landscape,” Thesis, copyright 2003

[10] Michele A. McGuirl, Jennifer C. Lee, Julia G. Lyubovitsky, Chalita Thanyakoop, Jhon H. Richards, Harry B. Gray, Jay R. Winkler, “Cloning, heterologous expression, and characterization of recombinant class II cytochromes c from Rhodopseudomonas palustris,” BBA 1619, 23-28 (2003)

[11] F. Akif Tezcan, William M. Findley, Brian R. Crane, Scott A. Ross, Julia G. Lyubovitsky, Harry B. Gray, Jay R. Winkler, ”Employing Deeply Trapped Intermediates to Map Cytochrome c Folding Landscape,” Proc. Natl. Acad. Sci. USA 99, 8626-8630 (2002)

[12] Julia G. Lyubovitsky, Harry B. Gray, Jay R. Winkler, “Structural Features of the Cytochrome c Molten Globule Revealed by Fluorescence Energy Transfer Kinetics,” J. Am Chem. Soc.124, 14840-14841(2002)

[13] Julia G. Lyubovitsky, Harry B. Gray, Jay R. Winkler, ”Mapping the Cytochrome c Folding Landscape,” J. Am Chem. Soc.124, 5481-5485 (2002)

[14] Maynard J. Kong, Andrew V. Teplyakov, J. Jagmohan, Julia G. Lyubovitsky, C. Mui, Stacey F. Bent, “Interaction of C-6 cyclic hydrocarbons with Si(100)-2x1 surface: Adsorption and hydrogenation reactions,” J. Phys. Chem. B 104: (14) 3000-3007 (2000)

[15] Maynard J. Kong, Andrew V. Teplyakov, Julia G. Lyubovitsky, Stacey F. Bent, “NEXAFS studies of adsorption of benzene on Si(100)-2x1,” Surf. Sci. 411(3), 286-293 (1998)

[16] Maynard J. Kong, Szetsen S. Lee, Julia Lyubovitsky, and Stacey Bent, “Infrared Spectroscopy of Methyl Groups on Silicon,” Chemical Physics Letters 263, 1-7 (1996)

For additional information, please see Professor Lyubovitsky's faculty webpage.

http://www.engr.ucr.edu/~julial/
 

Biography

Dr. Lyubovitsky laboratory is pursuing interdisciplinary research spanning disciplines such as Chemistry, Biology, Physics and Engineering with a goal to develop molecular level understanding and control of protein/peptide assembly and disassembly and to apply this knowledge to diseases, tissue engineering, nanotechnology and biomaterials. A common theme is biomedical imaging and non-destructive optics techniques that we are developing to study these complex biological systems. The research projects in the group integrate technology/instrumentation development and experimental methodologies used in biochemistry and biology. The focus of our biological program is to design, to build, to understand bonding mechanisms and to test a new generation of protein-based materials and adhesives for medical applications. We are also interested in understanding the rules that govern assembly of extra-cellular proteins in general. We study assembly at both molecular (nanometer) and tissue (micron) levels and explore its effects on the cells. Our technology development program focuses on designing new methods and strategies to non-destructively probe bulk properties including structure and dynamics of constructed and naturally occurring biopolymers (connective tissues, biomaterials, bio-adhesives, etc.). Among the techniques we use are multi-photon optical imaging, scanning electron microscopy, fluorescence and Raman spectroscopies, solid state NMR and X-ray diffraction. We design experimental model systems, develop systematic characterization methods which include data analysis, use finite element modeling and generate theories to interpret our experiments.

For additional information, please see Professor Lyubovitsky's faculty webpage.

http://www.engr.ucr.edu/~julial/