University of California, Riverside

Bourns College of Engineering

Xin Ge

Faculty Profile

Faculty Profile

Xin Ge

Assistant Professor of Chemical and Environmental Engineering

Ph.D. Chemical Engineering
McMaster University, 2008

Bourns Hall B309
University of California, Riverside
Riverside, CA 92521

Telephone: 951-827-6229
Fax: 951-827-5696

Personal Webpage

Prior Institutions: University of Texas, Austin


Prior to joining BCOE, Xin Ge was a research associate at University of Texas at Austin, where he invented novel technologies for synthetic antibody library construction and therapeutic antibody discovery through next generation sequencing and bioinformatics. He was a post-doctoral fellow at McMaster University, where he developed biocompatible silica sol-gel materials for high-density microarrays of multiplexed kinase assays and whole-cell based biosensors. He earned his Ph.D. in chemical engineering from McMaster University in 2008, where he investigated the in vitro and in vivo phase partitioning phenomena of biopolymers (elastin-like polypeptides), exploited this unique and reversible behavior for recombinant protein biosynthesis, and developed a series of simple and cost-effective bioseparation methods. He received his M.S. in biochemical engineering in 2003 from Tsinghua University, where he generated antibodies for diagnostic applications by DNA immunization.


  • Ph.D. Chemical Engineering, McMaster University, 2008
  • M.S. Biochemical Engineering, Tsinghua University, 2003
  • B.S. Chemical Engineering, Tsinghua University, 2000


  • NSF CAREER, 2015-2020
  • Academic Senate Regents Fellowship, UCR, 2013-2014
  • NSERC Post-Doctoral Fellowship (Canada), 2008-2010
  • Chinese Government Award for Outstanding Self-financed Students Abroad, 2007
  • Ontario Graduate Scholarship, 2006-2007
  • E. Hameilec Graduate Student Award (McMaster), 2006

Research Topics

Therapeutic antibody discovery and engineering; directed evolution of enzymes, metabolic pathways and microbial stains; next generation DNA sequencing and bioinformatics; in vivo partitioning for biogenesis and bioremediation.

Environmental issues and depletion of fossil fuels are two major crises that modern chemical industry has to face currently. It is sorely needed for the development of more sustainable processes for the production of materials, chemicals and fuels. We believe tremendous opportunities lie in biological systems, since the large metabolic diversity can be exploited to achieve a wide variety of chemical conversions. In addition, bio-pharmaceuticals, comprised of monoclonal antibodies, therapeutic enzymes, vaccines and nucleic acids, have become an increasingly important presence in the therapeutics market for fighting cancers, genetic disorders, autoimmune diseases, and infections.

Coupling genetic engineering with a new generation of high-throughput approaches, researchers at the Ge Lab aim to develop sustainable biotechnologies for the “post-oil age”. Particularly, we are interested in: 1) discovery, engineering and production of monoclonal antibodies and antimicrobial agents that are biomedically important with broad therapeutic or diagnostic applications; 2) engineering and synthesis of recombinant biopolymers (e.g. spider silk, mussel byssus) that have stunning mechanical properties may not be achieved by chemically synthesized polymers; 3) combinatorial metabolic engineering of microbes for improved productivity of biofuels and specialty chemicals. Shortly, we anticipate using these sustainable biotechnologies to produce pharmaceuticals, materials, chemicals and fuels in eco-friendly and cost-effective manners.

Selected Publications

  • Nam, D.H.; Ge, X. Development of Periplasmic FRET-Based Screening Method for Protease Inhibitory Antibodies. Biotechnol. Bioeng. 110[11]: 2856-2864, 2013.
  • Ge, X.; Eleftheriou, N.M.; Dahoumane, S.A.; Brennan, J.D. Sol-Gel Derived Materials for Production of Pin-Printed Reporter Gene Living-Cell Microarrays. Anal. Chem. 85[24]: 12108-12117, 2013. 
  • Ge, X; Lebert, JM; Monton, MRN; Lautens, LL; Brennan JD. Materials Screening for Sol–Gel-Derived High-Density Multi-Kinase Microarrays. Chem. Mater. 23[16]: 3685–3691, 2011.
  • Ge, X.; Mazor, Y.; Hunicke-Smith, S.P.; Ellington, A.D.; Georgiou, G. Rapid Construction and Characterization of Synthetic Antibody Libraries Without DNA Amplification. Biotechnol. Bioeng. 106[3]: 347-357, 2010.
  • Reddy, S.T.; Ge, X.; Miklos, A.E.; Hughes, R.A.; Kang, S.H.; Hoi, K.H.; Chrysostomou,C.; Hunicke-Smith, S.P.; Iverson, B.L.; Tucker, P.W.; Ellington, A.D.; Georgiou, G. Monoclonal Antibodies Isolated Without Screening by Analyzing the Variable-Gene Repertoire of Plasma Cells. Nat. Biotechnol. 28[9]: 965–969, 2010. (Featured by Biotechniques News 10/5/2010)
  • Ge, X.; Hoare, T.; Filipe, C.D.M. Protein Based Aqueous-Multiphasic Systems. Langmuir 26[6]: 4087-4094, 2010.
  • Ge, X.; Conley, A.; Brandle, J.E.; Truant, R.; Filipe, C.D.M. In Vivo Formation of Protein Based Aqueous Microcompartments. J. Am. Chem. Soc. 131[25]: 9094-9099, 2009.
  • Ge, X.; Trabbic-Carlson, K.; Chilkoti, A.; Filipe, C. D. M. Purification of an Elastin Like Fusion Protein by Microfiltration. Biotechnol. Bioeng. 95[3]: 424-432, 2006.
  • Ge, X.; Yang, D.S.C.; Trabbic-Carlson, K.; Kim, B.; Chilkoti, A.; Filipe, C.D.M. Self-Cleavable Stimulus Responsive Tags for Protein Purification Without Chromatography. J. Am. Chem. Soc. 127[32]: 11228-11229, 2005. (Featured by Chem. & Eng. News 83[32]: 36, 2005; The Scientist 19[22]: 24, 2005; and Faculty of 1000 Biology 16089436)

More Information 

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

College Information

Bourns College of Engineering
446 Winston Chung Hall

Tel: (951) 827-5190
Fax: (951) 827-3188