Copyright 2016 Biomedical Microdevices Laboratory
 J Lu, MP Rao, NC MacDonald, D Khang, & TJ Webster. Acta Biomater 4(1):192-201, 2008.
 P Vandrangi, SC Gott, VGJ Rodgers, & MP Rao. MMB 2013.
 P Vandrangi, SC Gott, R Kozaka, MP Rao, & VGJ Rodgers. Circulation 128:A18077, 2013.
 MP Rao, J Lu, HP Aguilar, NC MacDonald, & TJ Webster. Hilton Head 2008.
 3. P Vandrangi, SC Gott, R Kozaka, VGJ Rodgers, & MP Rao. PLoS ONE 9(10):e111465, 2014.
 SC Gott, BA Jabola, & MP Rao. J Micromech Microeng 25(8):085016, 2015.
Research in this thrust focuses on developing
deeper understanding of how nanoscale surface
topography affects vascular cell response, and
applying this understanding towards rational
design of stents and other devices to elicit
therapeutically desirable outcomes.
Thus far, our in vitro studies on planar substrates
have shown that rationally-designed surface
nanopatterning can: a) enhance endothelial cell
(EC) adhesion and proliferation [1-3]; b) promote
elongated EC morphology reminiscent of the
native endothelium [1-3]; c) preferentially
enhance EC adhesion and proliferation over
smooth muscle cells under competitive co-culture
conditions ; and d) promote enhanced
atheroprotective factor expression in ECs [3,5].
Collectively, these results suggest potential for a
new paradigm where rationally-designed
nanopatterning provides a physical means for
complementing (or replacing) current
pharmacological intervention schemes for
mitigating adverse physiological responses to
stenting (i.e. restenosis & late stent thrombosis).
In parallel, we have been developing means for
evaluating cellular response to surface
nanopatterning in more physiologically-relevant
contexts, i.e. those that provide exposure to the
complex multicellular milieu, flow-induced shear,
and tissue-device interactions present in vivo.
The balloon-deployable nanopatterned stents
shown here represent the first attempt to develop
a device platform that will eventually provide such
capability, and do so in a manner consistent with
conventional vascular stents .
VGJ Rodgers, BIEN, UCR
K Ghosh, BIEN, UCR
G Xu, ME, UCR
Top: Scanning electron micrograph of
nanopatterned Ti stent (deployed).
Bottom: Surface of a nanopatterned
stent with 0.75 µm groove width grating
in heavily deformed region .
UCR Collaborative Seed Grant Program (PI: Rao)