A great wealth of knowledge has been accumulated regarding how individual neurons
and associated cells work, and technologies such as MRI provide access to how large
numbers of cells work collectively. The area in between these regimes has proven to
be more difficult to investigate, and is an exciting and rapidly growing field of
research. Current technology largely limits the analysis of neuronal processing to
single or small clusters of neurons using a variety of electrodes or the introduction
of exogenous chemical agents. My research goal is to apply minimally-invasive non-contact
optical techniques to answer questions involving the structure, viability, and activity
in nerves and neural networks with the twin goals of complementing current methodologies
and knowledge in neuroscience and finding ways to apply these discoveries clinically.
Two current projects are: 1) application of polarization-sensitive optical coherence
tomography for non-destructive quantitative assessment of nerve myelination, and 2)
detection of slight transient structural changes associated with action potential
propagation as a means to optically record nerve activity in a non-contact manner. B. Hyle Park's research interests include optical imaging techniques such as optical
coherence tomography to neuroscience.
AwardsNIH Pathway to Independence (PI) Award, 2007